At CxT Discovery, we are advancing high-risk discovery towards groundbreaking therapeutics. Across both industry and academia, the structural landscape for innovation has become increasingly risk averse, leaving a widening gap between what is scientifically possible and what is institutionally supported. We were founded to pursue scientific opportunities that conventional funding structures overlook—not because the ideas are less compelling, but because they require deeper exploration and a different risk tolerance than traditional biotech or academic settings can accommodate.
We are a team of scientists with decades of biological and drug discovery expertise, applying our creative energy to advance bold and underexplored directions in early-stage drug discovery. Our strategy integrates emerging insights in regulatory biology with advances in computation and protein science to identify new therapeutic mechanisms with transformative potential. By investigating and de-risking these approaches, we aim to produce tool compounds, mechanistic understanding, and open-access data that benefit both our internal pipeline and the broader scientific community—ensuring that promising discoveries are given the chance to reach their full therapeutic potential.
Protein-protein interactions (PPIs) form the foundation of cellular regulation, with many proteins competing for shared interaction partners in mutually exclusive binding relationships. This competitive regulatory logic represents a largely untapped dimension of cellular control that could reveal entirely new classes of therapeutic targets.
Rather than simply blocking individual interactions, we can strategically rebalance competitive protein networks by modulating the relative binding affinities between competing partners. This approach offers a fundamentally different logic for therapeutic intervention in cellular regulatory systems.
By targeting competitive protein interaction networks, we can potentially modulate entire regulatory pathways rather than single proteins, opening new avenues for treating diseases where traditional approaches have failed or where key targets were previously considered undruggable.
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